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参三七皂甙Rg1预适应对肥厚乳鼠心肌细胞缺氧复氧损伤的保护
CT：Aim11”activityofmyocardialNa．KAI'Pa∞willde-cnLBeIIfri8chemicalreper~sion．Thestudyaimedtoewduatetheprotec．riveeffectofthenlcorandil聃abloodcardioplegicagentonthemyocardialNa’．K’A11∞competedtotheacfivityofNa-KATPaBe硒ischemicrepe血iDD．MethodsU＆ingablood-pe而l∞d，parabiotic，且g∞d0rabbitmodel，Bi|∞nheartsfromJBnBne5ewhiterabbits’redividedintotwogroupsofeightsubjects：nicorandilgroup锄edWith100panol／Lnico-randil．Krebe-Henseleitandeachrabbitb1oodmixedon1：2ratio；hypex-kalemiccardioplegiagroupfilledwithSLThomas’liquor也eandrabbitbloodmixedon1：2mtioth20mmol／LK‘．Bothheartsoftwogroupaunde~went60minnorl~otherm／cischemicperfusionand也蚰60rainrepe~fu．siomThech|ofNa-KATP~e眦ga￡edbofomand妇car-diacischemiabyelectronmicroscopicenzymecytochemicaltech-nique．ResultsThesctivi仃ofNa-KATPasereducedsignificantlyafterischemia／reperfusioninbothgroupe．Thechan目∞oftheNa’．K’ATPasewe∞mo∞obviOU8in也ehyperkalemiccardioplegiagroupthan也o。eof也enioorandilgroup．Conde~lenThenioorandilbloodcar~ople西aiseffectiveinprDtec吐ngthemyocardialNa*-KATPMe．taCTWORld：nioonmdil；cardioplegiaeolufiom；Na(+)一K(十)一exchangingATPase摘耍：目的缺血再灌注损伤会导致心肌细胞№．K+ATP酶活性降低，通过对比缺血再灌注后Na．K’ATP酶活性改变，研究尼可地尔含血停搏液对心肌细胞№．K’ATP酶的保护作用。方法采用问生态离体兔心共生支持系统模童。16个心脏随机分为两组。每组8只。分别采用尼可地尔超极化含血停勇IIj葭或者高钾去极化含血停跳液灌注。超极化含血停跳液由尼可地尔(100panol／L)，Krebe．Henseleit液和兔血1：2混合配制。去极化停搏液由St．Thomas’液与兔血1：2混合配毒《。最终K浓度20mmol／L。心脏停跳后以含血停跳液间断灌注，常温缺血60rain。再灌注60rain。采用电镜爵化学方法检测缺血前后心脏Na．K+ATP冀的变化。结暴缺血再灌注后两组中爵的活性均明显降低，高钾组较尼可地尔组减少更明显。结论尼可地尔对心肌细胞Na+．KATP爵缺血再灌注损伤有保护作用。主一词：尼可地尔；心麻痹液；Na(+)K(+)交换ATP冀n幢bH盯
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