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Domestic roxithromycin efficacy of treatment of respiratory tract infections


Results in the treatment group raised in 38 cases (38 ), the control group ,[link widoczny dla zalogowanych], 8 down (26.7 ), two groups of pathogenic bacteria and bacteria were cleared . 7,[link widoczny dla zalogowanych], 1996 In addition to Table 2. Table 2 Distribution of bacteria and the clearance of the two groups *, > 0.05. 2.3 down 100 adverse reactions in the treatment group , 5 transferred mainly gastrointestinal reactions , including an adjustment for signs of mild friction , 4 cases Abdominal discomfort, but tolerable to the end of treatment . Adverse reactions accounted for 5.3 discussion Luo toxin (Roxithromyeinl 9 in the erythromycin derivatives on the structural modification . antimicrobial effect of roxithromycin mainly through bacterial cell membrane, and then bacterial ribosomal subunits to form 50's Reversible binding , thereby blocking the binding of transfer RNA and the polypeptide chain of displacement , inhibit bacterial protein synthesis . its broad antimicrobial spectrum than erythromycin and the antibacterial activity increased, the majority of respiratory pathogens such as Streptococcus pneumoniae , gold Staphylococcus aureus , Haemophilus influenzae , Moraxella catarrhalis have good antibacterial activity , and the internal lactam antibiotics ineffective intracellular pathogens such as Legionella , mycoplasma, chlamydia are valid. roxithromycin in gastric acid Stable ,[link widoczny dla zalogowanych], completely absorbed , long half-life , its blood concentration and tissue fluid were significantly higher than the red mold claims , and maintain a long time , good bioavailability , clinical use of low doses , side effects light. treatment results described in this article That , with the Shanghai Institute of Pharmaceutical Industry in Pudong pharmaceutical tablets in the treatment of roxithromycin produced 100 cases of respiratory tract infection the total effective rate was 91, and Romania was the total effective force 90 In contrast, its efficacy is similar to ( dead > 0. 051. roxithromycin bacterial clearance rate was 86.8 ,[link widoczny dla zalogowanych], and Romania have similar force (87.5%), P> 0.05. roxithromycin less side effects, mainly gastrointestinal reactions. The Drug half-life of up to 12 hours , easy to use , simply shake 2 per day orally ,[link widoczny dla zalogowanych], its price was cheaper than the imported Luo force , we believe that the clinical efficacy of roxithromycin in domestic and bacterial eradication rates have achieved satisfactory results Treatment of respiratory tract infections outside the hospital is a very appropriate choice , and has wide application in clinical future .