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RANKL/RANK-OPG系统&#21450

 
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lin91957
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PostPosted: Sun 8:01, 20 Mar 2011    Post subject: RANKL/RANK-OPG系统&#21450

RANKL/RANK/OPG系统及其在类风湿关节炎骨质破坏中的作用
ndsolubleinter-leukin一6receptorsinthesynovialfluidsfromrheumatoidarthritispatientsareresponsibleforosteoclast-likecellformation.JBoneMinerRes,1996,l1:88—95.WongPK,QuinnJM,SimsNA,cta1.Interleukin-6modulatesproductionofTlymphocyte—-derivedcytokinesinantigen—-inducedarthritisanddrivesinflammation-inducedosteoclastogenesis.ArthritisRheum,2006,54:158—168.LubbertsE,KoendersMI,VandenBergWB.TheroleofT—cellinterleukin-17inconductingdestructivearthritis:lessonsfromanimalmodels.ArthritisResTher,2005,7:29—37.YasudaH.OPG,anti-RANKLantibody.NipponRinsho,2005.63:l647-1653.AnandarajahAP.SchwarzEM.Anti-RANKLtherapyforinflam-matorybonedisorders:Mechanismsandpotentialclinicalappli—cations.JCellBiochem,2006,97:226—232.
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